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-synuclein, which happens to be a principal element of Lewy bodies, in PARK 1 in 1997 and parkin in PARK two in 1998, which is an E3 ubiquitin ligase and results in endoplasmic reticulum (ER) pressure, propose that dysfunction in the intracellular proteinase methods, for instance ubiquitin-proteasome procedure or lysosomal method, which gets rid of
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